Observe first, there is hope! Some will escape the tribulation to come upon the earth and they will be left standing when Christ returns. The travail of the earth will not bend them nor break them, because God will remove them from harms way. So there is hope for some. But what must we do to be included in this elite number?
Notice the standard. One has to be counted worthy. Only those deemed fit will be spared from wrath and able to stand when Christ returns. What does one have to do to be "counted worthy?" The text doesn't say, but drawing upon a wider range of scripture here are three possibilities. First, it surely involves the imputed righteousness of Christ. One must be in Christ and clothed in His righteousness. What else? Positional righteousness must be fleshed out in practical righteousness (Rev. 19:8). That is you can't just be considered righteous, you have to live righeous. Finally, when it says to be counted worthy I think of John 15 and the Lord's emphasis on fruitfulness. The fruitful Christian has Jesus living through them (Gal. 5:22-23) and they are influcencing others toward Christlikeness (1 Cor. 11:1).
Finally notice the way to worthiness which involves both watching and praying. Watch current events, being wise like the sons of Issachar. Watch over those you are discipling, don't let any sheep stray. And watch over your own soul and purity. Then pray for God's kingdom to come in this world and in your family. Pray for the bride of Christ. Also see Mark 14:38.
An alert and praying Christian is valuable to the Lord and He will extend special protective graces to that individual much like He did to Noah in the days before the flood.